Services

Multidisciplinary Excellence

Our dedicated team of scientists are actively involved in building and sustaining multidisciplinary research collaborations. We also provide fee-for-service opportunities to utilize our capabilities as follows:

-Small Molecule Synthesis: We are equipped with capabilities to carry out synthetic organic chemistry protocols. Our capabilities include route design for synthesis, optimizing small molecules for improved drug-like properties and potency, and scale-up synthesis. We also have experience in synthesizing lipids and small peptides.

-Preparatory HPLC and FPLC Purification: We maintain a Waters PREP 150 preparatory high-performance liquid chromatography (HPLC) instrument for small molecule and peptide purification. We are also equipped with an ӒKTA pure™ fast protein liquid chromatography (FPLC) system for purifying and characterizing biomolecules.

-NMR Spectroscopy: Our Bruker 400 MHz NMR spectroscopy is used to characterize small molecule structures. Our instrument allows for measuring 5 major nuclei (¹H, ¹³C, ¹⁵N, ¹⁹F, and ³¹P). We also offer 2D experiments including COSY (Correlation Spectroscopy), TOCSY (Total Correlation Spectroscopy), NOESY (Nuclear Overhauser Effect Spectroscopy), HSQC (Heteronuclear Single Quantum Coherence), and HMQC (Heteronuclear Multiple Quantum Coherence).

-LC-MS/MS Analysis: Our Sciex 4500 liquid chromatography QTRAP mass spectrometer (LC-MS/MS) instrumentation allows us to analyze a multitude of compounds with exceptional sensitivity and specificity from proteomic/peptidomic/metabolomic profiling to pharmaceutical analysis and environmental monitoring. We are also experienced in quantifying compounds in biological matrices for pharmacokinetic analyses.

-ITC: Isothermal Titration Calorimetry (ITC) enables the measurement of binding affinities and thermodynamic profiles for intermolecular interactions.

–Computational Chemistry: Our computational capabilities include molecular dynamic simulations, docking, and quantum calculations.

• *The programs and services offered by George Mason University are open to all who seek them. George Mason does not discriminate on the basis of race, color, religion, ethnic national origin (including shared ancestry and/or ethnic characteristics), sex, disability, military status (including veteran status), sexual orientation, gender identity, gender expression, age, marital status, pregnancy status, genetic information, or any other characteristic protected by law. After an initial review of its policies and practices, the university affirms its commitment to meet all federal mandates as articulated in federal law, as well as recent executive orders and federal agency directives.